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Download Bioactive Lipid Mediators: Current Reviews and Protocols by Takehiko Yokomizo, Makoto Murakami PDF

By Takehiko Yokomizo, Makoto Murakami

This booklet summarizes the newest growth within the experiences of lipid mediators from the molecular to scientific point and introduces newly created instruments for research together with imaging mass spectrometry. Comprising 29 chapters divided into 4 significant components, the e-book describes the molecular natures of enzymes, transporters, and receptors for lipid mediators (Part I), the functionality of lipid mediators in Drosophila and Zebrafish (Part II), the relationships among lipid mediators and diverse illnesses (Part III), and targeted strategies of extraction, instruction, and quantification of lipid mediators (Part IV). learn on lipid mediators first and foremost began with research of the motion of aspirin, and next biochemical experiments pointed out many enzymes and receptors chargeable for the biosynthesis and sign transduction of person lipid mediators. throughout the phenotypic analyses of transgenic and knockout mice, it's been proven that the dysregulation of a few lipid mediators motives inflammatory, immune, or oncogenic issues. Lipid mediators have attracted elevated consciousness simply because their constructions are conserved between diverse species, and their biosynthetic and signaling pathways were deciphered on the molecular point. Many medicines that focus on lipid mediators are already getting used in hospitals, and this publication indicates extra probabilities for improvement of a wide selection of such medicinal drugs. Very lately, hugely delicate mass spectrometry has began for use to spot novel lipid mediators which are current basically in hint quantities in tissues yet with strong organic job. Written via overseas specialists, this ebook offers readers a accomplished view of lipid mediators and similar subject matters and is helping within the strategy of picking out examine objectives for the close to destiny.

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Extra info for Bioactive Lipid Mediators: Current Reviews and Protocols

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Murakami (*) • Y. jp © Springer Japan 2015 T. Yokomizo, M. 1007/978-4-431-55669-5_2 23 24 M. Murakami and Y. Taketomi mammals, and these have been subdivided into several groups based on their structures, catalytic mechanisms, localizations. and evolutionary relationships. The cPLA2 family contains 6 enzymes (cPLA2α−ζ), which (except for cPLA2γ) contain an N-terminal C2 domain for Ca2+-dependent association with the membrane. The iPLA2 or patatin-like phospholipase domain-containing lipase (PNPLA) family includes 9 enzymes, some of which act principally on phospholipids and others on neutral lipids such as triglyceride (TG).

Munoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR (2009) Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice. Am J Physiol Lung Cell Mol Physiol 296(6):L879–L887. 2008 63. Gesquiere L, Cho W, Subbaiah PV (2002) Role of group IIa and group V secretory phospholipases A2 in the metabolism of lipoproteins. Substrate specificities of the enzymes and the regulation of their activities by sphingomyelin. Biochemistry 41(15):4911–4920 64. Bostrom MA, Boyanovsky BB, Jordan CT, Wadsworth MP, Taatjes DJ, de Beer FC, Webb NR (2007) Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice.

Taketomi 30. Li H, Zhao Z, Wei G, Yan L, Wang D, Zhang H, Sandusky GE, Turk J, Xu Y (2010) Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development. FASEB J 24(10):4103–4116. 10-161356 31. Yan W, Jenkins CM, Han X, Mancuso DJ, Sims HF, Yang K, Gross RW (2005) The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calciumindependent phospholipase A2γ: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.

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