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Download Applications of Antisense Therapies to Restenosis by Alan D. Simon M.D., Mark K. Warshofsky M.D. (auth.), LeRoy PDF

By Alan D. Simon M.D., Mark K. Warshofsky M.D. (auth.), LeRoy E. Rabbani M.D. (eds.)

Restenosis, the proliferation of soft muscle cells (SMC) that line blood vessels, usually follows angioplasty. regardless of advances in cardiology, restenosis maintains to impact as much as forty% of the over 500,000 sufferers who suffer angioplasty every year.
Applications of Antisense remedies to Restenosis is the 1st quantity to handle the potential for utilizing antisense treatments to inhibit the restenosis that happens after percutaneous transluminal angioplasty and coronary stenting. The paintings severely examines the applying of varied antisense treatments for inhibiting restenosis.

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J. Am. Coli. Cardiol. 1991 ;17: 1533-1560. Kohchi K, Takebayashi S, Hiroki T, Nobuyoshi M. Signiticance of adventitial inflammation of the coronary artery in patients with un&1able angina: results at autopsy. Circulation. 1985;71:709-716. Booth RFG, Martin JF, Honey AC, Hassall DG, Beesley JE, Moncada S. Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipUlation. Atherosclerosis. 1989;76:257-268. Prescott MF, McBride CK. Court M. Development of intimal lesions after leukocyte migration into the vascular wall.

Known as myofibroblasts, these cells are considered to be intermediate between muscle and fibroblast differentiation, sharing morphologic characteristics with both cell types (102). In distinction to the normal, rounded, quiescent contractile phenotype, myofibroblasts are elongated (resembling fibroblasts), especially receptive to 25 chemotactic and mitogenic growth factors (102) and able to secrete large amounts of extracellular matrix, including glycosaminoglycans, fibronectin, and collagen in varying amounts (103).

22. 23. 24. 25 . 26. 27. 28. 29. 30. 31 . 32. 33. 34. 35. 36. 37. 38. 39. 40. Mak K, and Topol EJ. Clinical trials to prevent restenosis after percutaneous coronary revascularization. Ann NY Acad Sci, 1997;811:255. Ip JH, Fuster V, Badimon L, et al. Syndromes of accelerated atherosclerosis: role of vascular injury and SMC proliferation. J Am Coli Cardiol, 1990;1:1667. Libby P, Swanson S, Tanaka H, et al. Immunopathology of coronary arteriosclerosis in transplanted hearts. J Heart Lung Tran~plantation, 1992;11:55.

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