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By Peter McLaughlin, Lester E. Robertson, Michael J. Keating (auth.), Fernando Cabanillas M.D., M. Alma Rodriguez M.D. (eds.)

Fernando Cabanillas In 1993, Fisher et al. released the result of a randomized trial evaluating 3 third-generation regimens opposed to the vintage CHOP mix. For a number of years, the oncology neighborhood were confident that the 3rd­ new release regimens have been truly enhanced to cut. It got here as a surprise to many who there has been no distinction in consequence among the 4 hands of this medical trial. The logical end is that CHOP is pretty much as good as any of the opposite regimens established in that learn. regrettably, this glorious research has been misinterpreted through many as proving that there has no longer been any development within the box of lymphoma over the past twenty years. moreover, it has ended in a fatalistic angle within the reasoning of many clinicians who believe that 'nothing works greater than CHOP' and for this reason that it's not worthy checking out new medicines or constructing novel regimens. despite the fact that, the method during which we circulate ahead within the oncology box is seldom by means of dramatic breakthroughs. often, what seems to be first and foremost look to be a leap forward seems later to be only a modest breakthrough. a number of steps ahead ultimately upload as much as a tremendous increase, yet this develop is going overlooked due to the gradual nature of the method. during this quantity, we have now selected to debate a number of of those steps, which we suppose are sincerely creating a confident influence at the box of lymphomas and which quickly should still make a big distinction in healing results.

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Leuk Lymphoma 5 (Suppl):133-138. 7. Juliusson G, Liliemark J (1993). High complete remission rate from 2-chloro-2'deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count. J Clin Oncol11:679-689. 8. Kay AC, Saven A, Carrera CJ, Carson DA, Beutler E, Piro LD (1992). 2Chlorodeoxyadenosine treatment of low-grade lymphomas. J Clin OncoI10:371-377. 9. Hoffman M, Tallman M, Hakimian D, et al. (1994). 2-Chlorodeoxyadenosine is an active salvage therapy in advanced indolent non-Hodkin's lymphoma.

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