By Y. Kazuki, T. C. Schulz, T. Shinohara, M. Kadota (auth.), Prof. Dr. G. Lubec (eds.)
"Advances in Down Syndrome learn” represents up to date study in different parts of Down Syndrome (DS). a brand new promising animal version of DS is said and this opens new possibilities to check pathomechanisms and pharmacological techniques because it is greater than tricky to hold out reviews in people and the medical beneficial properties are hugely variable. by way of biology, cellphone cycle and stem mobilephone experiences and by way of biochemistry, relevance of reports on a selected protein kinase, channels, transporters, superoxide dismutase, antioxidant process, chromosome meeting issue and different vital organic constructions are supplied. And back, the gene dosage speculation is addressed and even though the majority of chromosome 21 gene items is unchanged in fetal DS mind, a number of particular chromosome 21 encoded constructions together with transcription elements are certainly overexpressed even supposing findings in fetal DS are diversified from these in grownup DS mind whilst Alzheimer-like neuropathology supervenes.
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Three littermate pairs (aged 4--6 months, except for Gart where mice were 12 months) were analyzed in 3-5 replicates. Signals were normalized for protein load using antibodies to tubulin or Rip140 (not shown). B Protein levels in Ts65Dn vs normal controls were quantitated from the Westerns in A. Consistent with the images, Sod1 and Ets2 showed no increases in trisomy. The short isoforms of Itsn1 and Gart show lesser increases than the long forms K. Gardiner 32 affected. In contrast, Sod1 and Ets2 protein levels are unchanged in the same trisomy samples.
In addition, for subsets of genes functioning within a common pathway or process, again not all are trisomic in the mouse models. These points suggest that phenotypic effects of trisomy on these pathways cannot be completely reproduced in current mouse models. e. 50% increases in activity of all trisomic genes, cannot be assumed. Of the seven chromosome 21 encoded proteins evaluated here, five showed gene dosage-related increases in 4-6 (or 12) month mouse brain and two, Ets2 and, surprisingly, Sod1, showed no increases.
2000). , 1999). , 2003). Herein, however, SIM2 levels were statistically comparable between DS, AD and controls although SIM2 levels were increased. Re-analysis with a higher number of brain samples may reveal a statistically proven increase, in this study we focused on a small but homogeneous cohort and the male sex exclusively. The inherent problems of postmortem specimen and vast variety of human expression of DS and AD may be solved by testing hundreds of specimen with multivariance analysis only.