By Ashutosh Tiwari, Bora Garipcan, Lokman Uzun
The booklet outlines first the significance of additional mobile Matrix (ECM), that's a common floor for many of cells. within the following chapters the effect of organic, chemical, mechanical, and actual homes of surfaces in micro and nano-scale on stem phone habit are mentioned together with the mechanotransduction. Biomimetic and bioinspired ways are highlighted for constructing microenvironment of a number of tissues, and floor engineering functions are mentioned in tissue engineering, regenerative medication and various form of biomaterials in numerous chapters of the book.
This e-book brings jointly cutting edge methodologies and methods followed within the study and improvement of Advanced Surfaces in Stem telephone Research. famous all over the world researchers planned matters including:
- Extracellular matrix proteins for stem mobile fate
- The superficial mechanical and actual homes of matrix microenvironment as stem mobilephone destiny regulator
- Effects of mechanotransduction on stem mobilephone behavior
- Modulation of stem cells habit via bioactive surfaces
- Influence of managed micro and nanoengineered surfaces on stem mobile fate
- Nanostructured polymeric surfaces for stem cells
- Laser floor amendment concepts and stem cells applications
- Plasma polymer deposition: a flexible instrument for stem phone research
- Application of bioreactor suggestion and modeling strategies in bone regeneration and augmentation treatments
- Substrates and surfaces for keep an eye on of pluripotent stem mobile destiny and function
- Application of biopolymer-based, floor changed units in transplant medication and tissue engineering
- Silk as a usual biopolymer for tissue engineering
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Additional resources for Advanced Surfaces for Stem Cell Research
Fibronectin- and collagen-mimetic ligands regulate bone marrow stromal cell chondrogenesis Extracellular Matrix Proteins for Stem Cell Fate 21 in three-dimensional hydrogels. Eur. Cell. Mater. 22, 168–76, discussion 76–7, 2011. 92. J. The collagen I mimetic peptide DGEA enhances an osteogenic phenotype in mesenchymal stem cells when presented from cell-encapsulating hydrogels. J. Biomed. Mater. Res. A. 103, 3516–25, 2015. 93. A. Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.
Alloying polymer(s) with poor mechanical properties and polymer(s) with better mechanical behavior strengthens its mechanical properties. For example, poly(lactic-co-glycolic acid) (PLGA) as synthetic biodegradable polymer and two natural proteins gelatin (denatured collagen) and α-elastin were blended to improve elastin elasticity . Microscopic evaluation confirmed that myoblasts reached confluence on the scaffold surfaces while simultaneously growing into the scaffolds. This polymeric blend can be useful for engineering soft tissues, such as heart, lung, and blood vessels.
This can open new prospects in tissue engineering based on engineered surface structures of scaffolds as microenvironments. 1 Introduction The cellular niche is a microenvironment or sheltering environment including from intrinsic and extrinsic mechanisms to control self-renewal and differentiation of stem cells (embryonic stem cells, tissue stem cells, and induced pluripotent stem cells) . The cellular niche maintains the stem cells from differentiation stimuli, apoptotic stimuli, and other stimuli that would challenge stem cell reserves.